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Hyaluronic acid is a high molecular weight polysaccharide with D- glucuronic acid and N-acetyl-glucosamine as repeating structure unit. Because of the action of hydrogen bond between the monosaccharide in HA linear axle, HA molecular forms a rigid screw column structure in space. Strong hydrophilic properties exist due to the large amount of hydroxyl groups. Furthermore, HA has a special water binding function and binds its water very strongly, so that it has strong water retention. Theoretically its binding water capacity is up to 500 ml/g as an ideal natural moisturizing factor.
HA is also one important component of the skin. It can prevent skin from aging and improve the appearance and tactile sensation of skin.
A part of low molecular weight HA can penetrate into dermal layer to control the mid-metabolism, and make the skin moist, smooth and elastic. Therefore the cosmetic functions of HA are its resistance against skin wrinkles and its general health protection. HA is not only a good skin moisturizer, but also promotes cell’s metabolism of skin. So HA stands for bio-mimetic cosmetics. The content of hyaluronic acid in body will decrease as they are aging, oral hyaluronic acid supplementation can supplement HA in body and improve skin conditions, moisturizing skin from the inside out, smoothing out wrinkles during cell metabolism. Oral hyaluronic acid Supplementation is very popular in Japan, USA and other western countries.
Hyaluronic acid is a natural part of the human body why it is highly suitable for many applications within the field of medicine and related aids. It is used in ophthalmology, orthopedics and cosmetic surgery. With the researching and development of application in medicine area, hyaluronic acid’s application as HA-supplementation and medical treatment material will be one major stream in health care Industry.
Cosmetic grade sodium hyaluronate
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Item
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standard |
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Appearance |
white powder or granular |
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D-glucuronic acid |
≥44.0%
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Protein |
≤0.1%
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Loss on drying |
≤10.0%
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Transparency (0.1%solution) |
≥99.0%
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PH(0.1% solution) |
5.5～7.5
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Heavy metal |
≤2×10-5 9/9
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Total aerobic plate count |
≤100 CFU/9
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Escherichia Coil |
Absent |
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Salmonella |
Absent |
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Staphylococcus Aureus |
Absent |
Molecular weight including: 0.01×106～3.0×106 Da
Shelf life:
Product in powder or granular form should be 24 months.
1%solution should be 12 months.
Packing and storage:
Package specification: 0.1kg/bottle, 0.5kgs/Al-foil bag, 1.0 kgs/Al-foil bag, 2.0 kgs/Al-foil bag, 5.0 kgs/Al-foil bag or as per customers' requirements.
Note:
1. This product intends to absorb moisture. Therefore it shouldn’t be exposed under moisture conditions for long time and should be kept under cool, sun-proof as well as airproof conditions. Hyaluronic acid is macromolecule polysaccharide with glucuronic acid and N-acetyl-glucosamine as repeating structure unit, therefore the content of Hyaluronic acid is analyzed by calibration of glucuronic acid content. Hyaluronic acid should be avoided mixing with the surface active agent with many cations because it is a kind of compound with many anions. Or it will be precipitated.
2. Hyaluronic acid is a high molecular weight substance and hard to be dissolved. It should be added into water slowly and stir the water avoiding hyaluronic acid forming agglomeration. You can have solution heated to accelerate its dissolving and it should not exceed 60℃.
3. Hyaluronic acid is a kind of polysaccharide and is sensitive to be infected by microbe. It should be used out one bottle or bag after unsealing. If there is some remainder in it, please tighten the film and seal the bottle or bag against moisture.
4. Dissolving hyaluronic acid with sterilized distilled water or deionized water is much better for storage. It should be used out one time after dissolving, or should be kept sealed. Also it can be added some preservative.
"DALI" Hyaluronic acid has specific advantages as follows:
(1). "DALI" Hyaluronic acid has high purification of more than 91%, with D-glucuronic acid content being more than 44%.
(2). Since "DALI" Hyaluronic acid is fine classified in terms of different molecular weight , it can be tailored for customers with various of requirements.
(3). Protein content in "DALI" Hyaluronic acid is so low that it can be rarely detected by Bradford method, thus hypersensitivity is prevented when using cosmetics made from "DALI" Hyaluronic acid;
(4). Key equipment and materials are imported for good quality. And all materials are non-animal sources then uncertain infection from animals is avoided so that HA product quality is guaranteed.
(5). Its solution has high transparency of more than 99%, so it can be widely used in cosmetic area.
Application of hayluronic acid:
Hyaluronic acid exists naturally in all living organisms and is a universal component of the spaces between the cells of body tissues (extracellular space) and eye vitreous body. It has special function:
1. .Moisturizing effect and Nutritional ingredient
2. Thickening, Lubricating and membrane-forming
3.Sun-screening and restoration of skin trauma
Recommended: 0.05%~0.5%